Abstract
Two new secoiridoids, swerpatic acid (1) with an unusual C8 skeleton and swerpalactone (2), were isolated along with ten known compounds (3–12) from the whole plants of Swertia patens. Their structures were elucidated by comprehensive spectroscopic analyses. Eight compounds were evaluated for their anti-hepatitis B virus (HBV) activities on Hep G 2.2.15 cell line in vitro. Compounds 4 and 10 showed moderate inhibitory activities on the secretion of HBsAg with IC50 values of 1.96 and 0.50 mM.
Acknowledgments
We thank the financial support from the Natural National Science Foundation of China for Distinguished Young Scholars (No. 81025023), the West Light Foundation of the Chinese Academy of Sciences, the Youth Innovation Promotion Association, CAS. And we are also grateful to the staff of the analytical group of the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences.
Disclosure statement
No potential conflict of interest was reported by the authors.