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Journal of Asian Natural Products Research Volume 18, 2016 - Issue 8
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One new linear C14 polyacetylene glucoside with antiadipogenic activities on 3T3-L1 cells from the capitula of Coreopsis tinctoria

Dan DuWest China-Washington Mitochondria and Metabolism Center, West China Hospital/West China Medical School, Sichuan University, Chengdu610041, China
,
Tao JinDepartment of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu610041, China
,
Zhi-Hua XingLaboratory of Ethnopharmacology, West China Hospital/West China Medical School, Sichuan University, Chengdu610041, China
,
Li-Qiang HuWest China-Washington Mitochondria and Metabolism Center, West China Hospital/West China Medical School, Sichuan University, Chengdu610041, China
,
Dan LongKey Laboratory of Transplant Engineering and Immunology, Ministry of Health, West China Hospital, Sichuan University, Chengdu610041, China
,
Sheng-Fu LiKey Laboratory of Transplant Engineering and Immunology, Ministry of Health, West China Hospital, Sichuan University, Chengdu610041, ChinaCorrespondence[email protected]
&
Meng GongWest China-Washington Mitochondria and Metabolism Center, West China Hospital/West China Medical School, Sichuan University, Chengdu610041, ChinaCorrespondence[email protected]
 show all
Pages 784-790 | Received 22 Oct 2015, Accepted 30 Jan 2016, Published online: 09 Mar 2016
 
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Abstract

Based on characteristic UV spectrum of the ene-diyne chromophore, one new polyacetylene glucoside and three known polyacetylene glucosides have been isolated from the EtOH extract of Coreopsis tinctoria. Their chemical structures were determined by detailed spectroscopic analysis and by comparison with literature data. Compounds 1–2 were tested for their antiadipogenic effects on 3T3-L1 adipocytes, and both of them reduced lipid accumulation dose-dependently in 3T3-L1 adipocytes.

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