Advanced search
Publication Cover
Journal of Asian Natural Products Research Volume 19, 2017 - Issue 7
Submit an article Journal homepage
204
Views
5
CrossRef citations to date
0
Altmetric
Original Articles

Microbial transformation of the anti-diabetic agent corosolic acid by Cunninghamella echinulata

Xu FengNavy Medical Research Institute, Shanghai 200433, China
,
Yan-Hua LuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200207, China
,
Zhen LiuNavy Medical Research Institute, Shanghai 200433, China;Shanghai Ocean University, Shanghai 201306, China
,
Dai-Ping LiNavy Medical Research Institute, Shanghai 200433, China
,
Ying-Xin ZouNavy Medical Research Institute, Shanghai 200433, China
,
Yi-Qun FangNavy Medical Research Institute, Shanghai 200433, China
&
Zhi-Yong ChuNavy Medical Research Institute, Shanghai 200433, ChinaCorrespondence[email protected]
 show all
Pages 645-650 | Received 08 Mar 2016, Accepted 03 May 2016, Published online: 30 May 2016
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

The pentacyclic triterpenoid corosolic acid was metabolized by Cunninghamella echinulata CGMCC 3.2000 to its C-24 aldehyde group metabolite and five other hydroxylated metabolites: madasiatic acid (2), 2α, 3β, 7β-trihydroxyurs-12-en-28-oic acid (3), 2α, 3β, 15α-trihydroxyurs-12-en-28-oic acid (4), 2α, 3β, 6β, 7β-tetrahydroxyurs-12-en-28-oic acid (5), 2α, 3β, 7β, 15α-tetrahydroxyurs-12-en-28-oic acid (6), and 2α, 3β,7β-trihydroxy-24-al-urs-12-en-28-oic acid (7); compounds 3, 5, and 7 were new compounds. The α-glucosidase inhibitory effects of the metabolites were also evaluated.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 426.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.