Cytototoxic constituents from the bark of Chisocheton cumingianus (Meliaceae)

Abstract

A new lanostane-type triterpenoid, 3β-hydroxy-25-ethyl-lanost-9(11),24(24′)-diene (1), along with 3β-hydroxy-lanost-7-ene (2) and β-sitosterol-3-O-acetate (3) was isolated from the stem bark of C. cumingianus. The chemical structure of the new compound was elucidated on the basis of spectroscopic data. All of the compounds were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1-3 showed cytotoxicity against P-388 murine leukemia cells with IC₅₀ values of 28.8 ± 0.10, 4.29 ± 0.03, and 100.18 ± 0.16 μg/ml, respectively.

Keywords:

• Lanostane-type triterpenoid
• Chisocheton cumingianus
• cytotoxic activity
• Meliaceae

Acknowledgments

We thank Dr Ahmad Darmawan and Mrs. Sofa Fajriah in the Research Center for Chemistry, Indonesian Science Institute, for NMR measurements. We are grateful to Mr. Uji Pratomo at Central Laboratory, Universitas Padjadjaran, Jatinangor, Indonesia for HR-TOFMS measurements.