Chemical constituents from the stems of Hydrangea paniculata

Abstract

Further study on the constituents from the stems of Hydrangea paniculata Sieb resulted in isolation of two new compounds 1–2, including 1 monoterpenoid and 1 phenolic glycoside, along with 10 known compounds. Their structures were elucidated on the basis of spectroscopic data, including UV, IR, MS, and NMR experiments, along with chemical methods. At 10 μM, compounds 1 and 2 exhibited comparable activities with bicyclol in vitro assays for hepatoprotective activity against APAP-induced HepG2 cell damage.

Keywords:

• Saxifragineae
• Hydrangea paniculata
• monoterpenoid
• phenolic glycoside
• hepatoprotective

Acknowledgments

We are thankful to the Department of Instrumental Analysis, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, for the measurements of spectroscopic data.