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Journal of Asian Natural Products Research Volume 19, 2017 - Issue 10
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Articles

Two new guaiane-type sesquiterpenoids from Valeriana hardwickii and their cytotoxicity

Man-Yuan WangSchool of Traditional Chinese Medicine, Capital Medical University, Beijing100069, China
,
Yong-Song ZhaiSchool of Traditional Chinese Medicine, Capital Medical University, Beijing100069, China
&
Chun-Hui LiangPharmacy Department, The Third Hospital of Hebei Medical University, Shijiazhuang050000, ChinaCorrespondence[email protected]
Pages 987-992 | Received 19 Apr 2017, Accepted 04 Jun 2017, Published online: 25 Jun 2017
 
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Abstract

Two new guaiane-type sesquiterpenoids, named 4α,5α-epoxy-8β-hydroxy-1α-hydro-α-guaiene (1) and 4α,5α-epoxy-1-hydroxy-α-guaiene (2), were isolated from the whole plants of Valeriana hardwickii. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 1 and 2 showed weak cytotoxicity against the lung adenocarcinoma (A549) and hepatoma (Bel7402) cell lines with IC50 values of 9.2 and 8.5 μM, respectively.

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