Cytotoxic lignans from the barks of Juglans mandshurica

Abstract

Phytochemical investigation of the barks of Juglans mandshurica Maxim led to the isolation, purification, and identification of one new lignan named Juglansol A (1), along with nine known compounds (2–10). Their structures were determined by the results of UV, IR, CD, HRESIMS, 1D, and 2D NMR spectroscopic analysis. Compounds 1–10 were evaluated for their cytotoxicities against A549, HepG2, Hep3B, Bcap-37, and MCF-7 cell lines. The results showed that compound 2 possessed stronger cytotoxicities against the tested tumor cell lines compared with positive control 5-fluorouracil.

Keywords:

• Juglans mandshurica
• lignans
• cytotoxicity
• structural elucidation

Acknowledgments

We kindly thank Yi Sha, Wen Li and Chao Huang of Shenyang Pharmaceutical University for recording the NMR spectra.