A new selaginellin derivative and a new triarylbenzophenone analog from the whole plant of Selaginella pulvinata

Abstract

Five selaginellin derivatives (1 and 3–6) including a new one, selaginellin T (1), and a new triarylbenzophenone analog, selagibenzophenone A (2), were isolated from the whole plants of Selaginella pulvinata. Their structures were determined by 1D- and 2D-NMR and HR-ESI-MS data. Selagibenzophenone A (2) is the first example of naturally occurring triarylbenzophenone. The results of the phosphodiesterase-4 (PDE4) inhibitory screening assays showed that compounds 1−6 exhibited potent activities with the IC₅₀ values in the range of 1.04−9.35 μM.

Keywords:

• Selaginellaceae
• Selaginella pulvinata
• selaginellin derivative
• triarylbenzophenone
• phosphodiesterase-4

Acknowledgments

The authors acknowledge the financial support from the National High Technology Research and Development Program of China, the Guangdong Natural Science Funds for Distinguished Young Scholar, the National Natural Science Foundation of China, and the Fundamental Research Funds for the Central Universities.