Furanone derivative and sesquiterpene from Antarctic marine-derived fungus Penicillium sp. S-1-18

Abstract

A new furanone derivative, butanolide A (1), and a new sesquiterpene, guignarderemophilane F (2), together with six known compounds, were isolated from the fungus Penicillium sp. S-1-18 derived from Antarctic marine. The new structures were determined by spectroscopic studies such as 1D- and 2D-NMR and MS analyses. The absolute configuration of 1 was determined by the modified Mosher’s method, while the absolute configuration of 2 was determined by calculated ECD spectroscopy. The isolated secondary metabolites were evaluated for their protein tyrosine phosphatase 1B (PTP1B) inhibitory activity. Compound 1 showed moderate inhibitory activity against PTP1B with IC₅₀ value of 27.4 μM.

Keywords:

• Penicillium sp
• furanone derivative
• sesquiterpene
• bioactivity

Acknowledgements

The authors thank Prof. B. Chen of Polar Research Institute of China to supply the Antarctic fungus Penicillium sp. S-1-18, and thank Prof. P. L. Li of Ocean University of China for the ECD calculation.