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Articles

Three new cytotoxic oleanane triterpenoid saponins from Cylindrokelupha dalatensis

, , , , , , & ORCID Icon show all
Pages 770-780 | Received 25 Mar 2017, Accepted 09 Oct 2017, Published online: 07 Nov 2017
 

Abstract

Three new minor oleanane triterpenoid saponins, cylindrosides B (1), C (2), and D (3), were isolated from the seed of Cylindrokelupha dalatensis using chromatographic method. Their structures were established on the basis of the chemical and spectroscopic evidences. They displayed significant antitumor activity in vitro against HL60 cancer cell lines and IC50 values were 7.15 ± 0.63, 10.07 ± 0.97, and 4.74 ± 0.57 μM, respectively, by MTT method.

Acknowledgments

We are grateful to Ms. Mei-feng Xu of the National Center of Biomedical Analysis (NCBA) for the measurements of the NMR spectra.

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