Three new cytotoxic oleanane triterpenoid saponins from Cylindrokelupha dalatensis

Abstract

Three new minor oleanane triterpenoid saponins, cylindrosides B (1), C (2), and D (3), were isolated from the seed of Cylindrokelupha dalatensis using chromatographic method. Their structures were established on the basis of the chemical and spectroscopic evidences. They displayed significant antitumor activity in vitro against HL60 cancer cell lines and IC₅₀ values were 7.15 ± 0.63, 10.07 ± 0.97, and 4.74 ± 0.57 μM, respectively, by MTT method.

Keywords:

• Cylindrokelupha dalatensis
• triterpenoid saponin
• cylindroside B
• cylindroside C
• cylindroside D

Acknowledgments

We are grateful to Ms. Mei-feng Xu of the National Center of Biomedical Analysis (NCBA) for the measurements of the NMR spectra.