Anti-inflammatory pterocarpanoids from the roots of Pongamia pinnata

Abstract

A phytochemical study on the roots of Pongamia pinnata afforded 11 pterocarpanoids, including three new compounds. The structures of the isolated compounds were determined by 1D and 2D NMR and HRESIMS data. The absolute configurations of the new compounds were assigned via analysis of the specific rotations and electronic circular dichroism (ECD) spectra. The isolates were evaluated for their inhibitory effects on nitric oxide (NO) production in LPS-stimulated BV-2 microglial cells. Six compounds exhibited inhibitory effects against NO production, and compound 5 showed the best activity with an IC₅₀ value at 12.0 μM.

Graphical Abstract

Keywords:

• Pongamia pinnata
• Leguminosae
• pterocarpanoids
• anti-inflammatory effect
• nitric oxide inhibition

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by National Key Technology R&D Program “New Drug Innovation” of China [grant No. 2018ZX09711001-008-003].