Advanced search
Publication Cover
Journal of Asian Natural Products Research Volume 21, 2019 - Issue 3
Submit an article Journal homepage
147
Views
4
CrossRef citations to date
0
Altmetric
Articles

Cytotoxic aspidosperma-type alkaloids from Melodinus axillaris

Lei FangSchool of Biological Science and Technology, University of Jinan, Jinan250022, China; ;State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin541004, ChinaORCID Iconhttp://orcid.org/0000-0003-3999-7170View further author information
ORCID Icon,
Tian-Tian HeSchool of Biological Science and Technology, University of Jinan, Jinan250022, China; View further author information
,
Kong-Kai ZhuSchool of Biological Science and Technology, University of Jinan, Jinan250022, China; View further author information
,
Miao ZhangSchool of Biological Science and Technology, University of Jinan, Jinan250022, China; Correspondence[email protected] [email protected]
View further author information
,
Jie ZhouSchool of Biological Science and Technology, University of Jinan, Jinan250022, China; Correspondence[email protected] [email protected]
View further author information
&
Hua ZhangSchool of Biological Science and Technology, University of Jinan, Jinan250022, China; View further author information
Pages 284-290 | Received 31 Aug 2018, Accepted 16 Dec 2018, Published online: 20 Jan 2019
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

One new aspidosperma-type alkaloid, melotenine A (1), together with five known ones (2–6), was isolated from the leaves of Melodinus axillaris. Their structures were elucidated by detailed spectroscopic analysis and quantum chemical ECD calculation. The isolated aspidosperma-type alkaloids were evaluated for their cytotoxicity against four human cancer cell lines and melotenine A showed significant cytotoxicity against all cells with IC50 values ranging from 0.6 to 1.5 μM.

Disclosure statement

The authors declare that there are no conflicts of interest.

Additional information

Funding

This work was financially supported by Natural Science Foundation of China (21772065, 81673527), Postdoctoral Science Foundation of China (2017M622268), Shandong Provincial Natural Science Foundation (ZR2017MH019, JQ201721), Shandong Provincial Key Research Project (2017GSF19115, 2018GSF118158), Shandong Talents Team Cultivation Plan of University Preponderant Discipline (No. 10027), and State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University) (CMEMR2016- B07).

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 426.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.