New compounds from the seeds of Psoralea corylifolia with their protein tyrosine phosphatase 1B inhibitory activity

Abstract

Two new flavonoids, 5,4′-dihydroxy-6,7-furanbavachalcone (1), 1″-methoxy-6,7-furanflavanone (2), together with five known compounds (3–7), were isolated from the seeds of Psoralea corylifolia. Their structures were elucidated by IR, UV, NMR, HRESMS experiments, and comparison of their NMR data with previously reported data. All compounds were evaluated for in vitro inhibitory activity against PTP1B. Additionally, the isolated compounds (1–6) displayed moderate inhibitory effects against PTP1B with IC₅₀ values ranging from 10.3 ± 0.9 to 25.1 ± 1.6 μM.

Graphical Abstract

Keywords:

• Leguminosae
• Psoralea corylifolia
• diabetes
• flavonoid
• PTP1B

Acknowledgments

We are grateful to the Department of Instrumental Analysis of Central South University for the measurement of the UV, IR, HRESIMS, and NMR.

Disclosure statement

No potential conflict of interest was reported by the authors.