One new and seven known triterpene glycosides from the aerial parts of Cimicifuga dahurica

Abstract

One new triterpene glycoside, asiaticoside I (1), along with seven known ones (2–8), were isolated from the aerial parts of Cimicifuga dahurica (Turcz.) Maxim. The structure of 1 was elucidated on the basis of extensive spectroscopic methods including 1D-NMR, 2D-NMR and MS data. The structures of known compounds were determined by comparison with the literature data. Compound 1 exhibited moderate cell growth inhibitory activities in vitro against HELF, non-small cell lung cancer A549, and pancreatic cancer PANC-1 cell lines, with IC₅₀ values of 62.97, 43.19, and 60.40 μM, respectively.

Graphical Abstract

Keywords:

• Ranunculaceae
• Cimicifuga dahurica
• the aerial part
• triterpene glycoside
• asiaticoside

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The work was financially supported by Doctoral Fund of Ministry of Education of China (no. 2018M633721), Natural Science Foundation of Liaoning Province of China (no. 2018055455) and Scientific Research Fund of Liaoning Provincial Education Department of China (no. 2017LQN09).