Abstract
A new prenylated coumarin (1) and a new anthranilamide derivative (2) were isolated from the aerial parts of Evodia lepta. Compound 2 represents the first anthranilamide derivative from the Evodia genus. Their structures were elucidated by spectroscopic data analysis (MS, UV, IR, and NMR). Compound 1 exhibited certain inhibition on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.7 macrophages with an IC50 value of 37.96 ± 1.7 μM.
Graphical Abstract
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Disclosure statement
No potential conflict of interest was reported by the authors.
Funding
This work was supported by the Natural Science Foundation of China (81573302 and 81722042), the Fundamental Research Funds for the Central Universities (17ykzd12), and the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (2017BT01Y093).