Production of 3-desmethyl protostreptovaricin I from the genetically engineered Streptomyces spectabilis CCTCC M2017417

Abstract

A new streptovaricin analogue, namely 3-desmethyl protostreptovaricin I (1), was isolated from the culture of the genetically engineered strain ΔstvM2 derived from Streptomyces spectabilis CCTCC M2017417. Its structure was elucidated on the basis of extensive spectroscopic analyses, including 1D and 2D NMR tests, and high resolution mass spectrometry analysis. Compound 1 is the first example of 3-desmethyl streptovaricin analogues reported so far, however, it showed no antibacterial activities against Staphylococcus aureus ATCC 29213.

Graphical abstract

Keywords:

• Streptovaricin
• Streptomyces spectabilis
• spectroscopic analyses

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the Research Start-up Funding of Hubei University of Education (Grant No. 19RC06 to Dr. Yuanzhen Liu), the Natural Science Foundation of Hubei Province, China (Grant No. 2019CFB595 to Dr. Yuanzhen Liu), and the Special Funding of Prevention and Cure of COVID-19, Hubei University of Education (Grant No. 20XGZX22 to Dr. Yuanzhen Liu).