1,8-Cineole: a review of source, biological activities, and application

Abstract

1,8-Cineole (also known as eucalyptol) is mostly extracted from the essential oils of plants, which showed extensively pharmacological properties including anti-inflammatory and antioxidant mainly via the regulation on NF-κB and Nrf2, and was used for the treatment of respiratory diseases and cardiovascular, etc. Although various administration routes have been used in the application of 1.8-cineole, few formulations have been developed to improve its stability and bioavailability. This review retrospects the researches on the source, biological activities, mechanisms, and application of 1,8-cineole since 2000, which provides a view for the further studies on the application and formulations of 1,8-cineole.

Graphical abstract

Keywords:

• 1,8-Cineole
• source
• biological activity
• mechanism
• application

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by National Natural Science Foundation of China (No. 81760725 and U1812403-4-4), the Fund of High Level Innovation Talents (No. 2015-4029), the Base of International Scientific and Technological Cooperation of Guizhou Province (No. [2017]5802), the Guizhou Provincial Natural Science Foundation (No. [2020]1Z069), the Initial Found for Ph.D. of Guizhou Medical University (No. YJ2018-006).