Capsulactone: a new 4-hydroxy-α-pyrone derivative from an endophytic fungus Penicillium capsulatum and its antimicrobial activity

Abstract

A new 4-hydroxy-α-pyrone, namely capsulactone (1), was isolated from an endophytic fungus Penicillium capsulatum XL027 obtained from the leaves of Panax notoginseng. The structure and absolute configuration of 1 were elucidated through a combination of spectroscopic data and computed methods, as well as by comparison with literature data. Compound 1 exhibited weak activity against methicinllin-resistant Staphylococcus aureus with an MIC value of 100 μg/ml.

Graphical Abstract

Keywords:

• Panax notoginseng
• Penicillium capsulatum
• pyrone
• capsulactone
• antimicrobial activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Key R&D Program of China (2020YFC1712700), National Natural Science Foundation of China (No. 81872755 and 82073714), the Talented Youth Cultivation Program from “the Fundamental Research Funds for the Central Universities,” South-Central University for Nationalities (No. CZP20008), and the Key Project of Yunnan Tobacco Industry Co. Ltd. (2020XY01).