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Journal of Asian Natural Products Research Volume 23, 2021 - Issue 11
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Research Article

Three new sesquineolignans from the fruits of Crataegus pinnatifida

Peng ZhaoKey Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, ChinaView further author information
,
Shuang QiuKey Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, ChinaView further author information
,
Xiao-Qi YuKey Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, ChinaView further author information
,
Guo-Dong YaoKey Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, ChinaView further author information
,
Xiao-Xiao HuangKey Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, ChinaORCID Iconhttps://orcid.org/0000-0003-0099-1118View further author information
ORCID Icon &
Shao-Jiang SongKey Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9074-2467View further author information
ORCID Icon
Pages 1051-1056 | Received 02 Apr 2020, Accepted 15 Nov 2020, Published online: 17 Dec 2020
 
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Abstract

Chemical investigations of the 75% EtOH extract from the fruits of Crataegus pinnatifida led to the isolation of three undescribed naturally occurring sesquineolignans with two 8-O-4'-type neolignan moieties, cratapinnatifidas A-C (1–3). Their chemical structures were elucidated by the comprehensive spectroscopic analyses (HRESIMS, 1D and 2D-NMR). In the bioactivity assay, their cytotoxic activities against two human hepatoma cell lines (HepG2 and Hep3B) were evaluated and no significant activity was seen with IC50 values ranging from 12.5 to 50.0 μM.

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Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by Career Development Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University (ZQN2018006) and the Project of Innovation Team Foundation (LT2015027).

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