Chemical constituents from Maackia amurensis and their anti-inflammatory and antioxidant activities

Abstract

A new flavonoid named (2S)-7,4′-dimethoxyl-6-(2″,3″-epoxy-3″-methylbutyl)flavanone (1), along with five known compounds (2–6), were isolated from the EtOAc-soluble extract of the stem bark of Maackia amurensis. Their structures were elucidated on the basis of spectroscopic methods. All compounds were evaluated for anti-inflammatory and antioxidant activities in vitro. Among them, compound 5 showed the highest inhibitory activity on NO production in RAW264.7 cells stimulated by LPS with IC₅₀ value of 59.0 ± 1.5 µM. Meanwhile, compounds 1–6 exhibited varying antioxidant activities through DPPH, ABTS free radical-scavenging and FRAP assays.

Graphical abstract

Keywords:

• Maackia amurensis
• leguminosae
• flavonoid
• anti-inflammatory
• antioxidant

Acknowledgements

We thank to the workers of Kunming Biotechnology Co., Ltd, and the colleagues of the Research Center for Chemistry, Guangzhou University of Chinese Medicine.

Disclosure statement

No potential conflict of interest was reported by the authors.