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Abstract
A chemical investigation on the roots of Aconitum episcopale afforded three undescribed aconitine–type C19–diterpenoid alkaloids, episcopalines A–C (1–3). The structures of the new compounds were elucidated by spectroscopic analysis (NMR, IR, UV, and MS). The isolated alkaloids were tested in vivo for their antinociceptive properties. As a result, episcopaline B (2) showed potent antinociceptive effect and its ID50 value (55.0 μmol/kg) was 2-fold less than those of the positive control drugs aspirin and acetaminophen.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was funded by the joint special fund project of the Applied Basic Research for local university in Yunnan Province [2019FH001(-033)], Special funds for reform and development of local university supported by the Central Finance (PL201707230369), and the National Undergraduate Training Programs for Innovation and Entrepreneurship (201910684029).