Structural modification and antihypertensive activity study of formononetin derivatives

Abstract

A series of formononetin derivatives with substituted benzyloxy groups on the 4′ position of isoflavone were designed and synthesized. Their vasodilative activities were evaluated by wire myograph system on isolated rat mesenteric arterial ring. The preliminary SAR of target compounds was thus discussed. Compounds 3d and 3e exhibited potent vasodilative activities against the rat mesenteric arterial rings induced contraction with K⁺. Compounds 3d and 3e also showed antihypertensive effects in SHRs by oral administration.

Graphical Abstract

Keywords:

• Formononetin derivatives
• structural modification
• vasodilative activity
• antihypertensive activity

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This study was financially supported by the Research Project of Hebei Administration of Chinese Medicine [No. 2019077] and Natural Science Foundation of Hebei Province, China [No. H2020423163].