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Journal of Asian Natural Products Research Volume 24, 2022 - Issue 12
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Articles

Hyperoside suppresses osteoclasts differentiation and function through downregulating TRAF6/p38 MAPK signaling pathway

Jun Zhua Key laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Collaborative Innovation Center for Mountain Ecology & Agro-Bioengineering (CICMEAB), Institute of Agro-bioengineering, College of Life Sciences, Guizhou University, Guiyang 550025, China;b National & Local Joint Engineering Research Center for the Exploitation of Homology Resources of Southwest Medicine and Food, Guizhou University, Guiyang 550025, ChinaView further author information
,
Min Zhangb National & Local Joint Engineering Research Center for the Exploitation of Homology Resources of Southwest Medicine and Food, Guizhou University, Guiyang 550025, ChinaView further author information
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Xiong-Li Liub National & Local Joint Engineering Research Center for the Exploitation of Homology Resources of Southwest Medicine and Food, Guizhou University, Guiyang 550025, ChinaView further author information
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Zhi-Gang Yina Key laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Collaborative Innovation Center for Mountain Ecology & Agro-Bioengineering (CICMEAB), Institute of Agro-bioengineering, College of Life Sciences, Guizhou University, Guiyang 550025, China;b National & Local Joint Engineering Research Center for the Exploitation of Homology Resources of Southwest Medicine and Food, Guizhou University, Guiyang 550025, ChinaView further author information
,
Xiao-Xue Hanb National & Local Joint Engineering Research Center for the Exploitation of Homology Resources of Southwest Medicine and Food, Guizhou University, Guiyang 550025, ChinaView further author information
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Hui-Juan Wangb National & Local Joint Engineering Research Center for the Exploitation of Homology Resources of Southwest Medicine and Food, Guizhou University, Guiyang 550025, ChinaCorrespondence[email protected] [email protected]
View further author information
&
Ying Zhoub National & Local Joint Engineering Research Center for the Exploitation of Homology Resources of Southwest Medicine and Food, Guizhou University, Guiyang 550025, China;c College of pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, ChinaView further author information
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Pages 1157-1168 | Received 07 Jul 2021, Accepted 16 Mar 2022, Published online: 18 Apr 2022
 
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Abstract

Hyperoside (HP), as a natural product, can promote proliferation and differentiation of osteoblasts and presents a protective effect on ovariectomized (OVX) mice. However, the inhibitory effect of HP on osteoclasts (OCs) and the potential mechanism remain to be elucidated. In this study, it was found that HP could effectively inhibit the differentiation and bone resorption of OCs, and its intrinsic molecular mechanism was related to the inhibition of TRAF6/p38 MAPK signaling pathway. Therefore, HP could be a promising natural compound for lytic bone diseases.

Graphical Abstract

Disclosure statement

The authors have no conflicting interests.

Additional information

Funding

This research was financially supported by the National Key R&D Program of China (2018YFC1708100); Guizhou Science and Technology Program (Qian Ke He Ji Chu ZK [2021] 520); Guizhou University Introduced Talent Research Project (Gui Da Ren Ji He Zi [2019] 29).

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