Antinociceptive diterpenoid alkaloids from the roots of Aconitum austroyunnanense

Abstract

A phytochemical investigation on the roots of Aconitum austroyunnanense afforded three undescribed aconitine–type C₁₉–diterpenoid alkaloids, austroyunnanines A–C (1–3). Structural elucidation of all the compounds were performed by spectral methods such as 1 D and 2 D (¹H–¹H COSY, HMQC, and HMBC) NMR spectroscopy. The isolated alkaloids were tested in vivo for their antinociceptive properties. Consequently, austroyunnanine B (2) exhibited significant antinociceptive effect and its ID₅₀ value (48.0 μmol/kg) was 2-fold less than those of the positive control drugs aspirin and acetaminophen.

Graphical Abstract

Keywords:

• Aconitum austroyunnanense
• Ranunculaceae
• C₁₉–diterpenoid alkaloid
• antinociceptive activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was funded by the joint special fund project of the Applied Basic Research for local university in Yunnan Province [2019FH001(-033)], Special funds for reform and development of local university supported by the Central Finance (PL201707230369), and the National Undergraduate Training Programs for Innovation and Entrepreneurship (201910684029).