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Journal of Asian Natural Products Research Volume 25, 2023 - Issue 2
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Research Articles

Two new isoflavones from the roots of Sophora tonkinensis

Dao-Jun Chena State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang550014, China;b Guizhou Bailing Enterprise Group Pharmaceutical Co., Ltd, Anshun561000, ChinaView further author information
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Shuang Yuana State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang550014, China;b Guizhou Bailing Enterprise Group Pharmaceutical Co., Ltd, Anshun561000, ChinaView further author information
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Peng Zhanga State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang550014, China;c The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang550002, China;d School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang550025, ChinaView further author information
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Qiao Ana State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang550014, China;c The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang550002, ChinaView further author information
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Ji-Bin Zoua State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang550014, China;c The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang550002, ChinaView further author information
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Chun-Mao Yuana State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang550014, China;c The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang550002, ChinaView further author information
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Li-Hua Zhaoe The Institute of Biotechnology and Germplasm Resources, Yunnan Academy of Agricultural Sciences, Kunming650204, ChinaCorrespondence[email protected]
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Zhan-Xing Hua State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang550014, China;c The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang550002, ChinaCorrespondence[email protected]
View further author information
&
Xiao-Jiang Haoa State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang550014, China;c The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang550002, China;f State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming650201, ChinaCorrespondence[email protected]
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Pages 163-170 | Received 18 Feb 2022, Accepted 09 May 2022, Published online: 08 Jun 2022
 
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Abstract

Two new isoflavones (1 and 2), as well as eight known ones were isolated from the roots of Sophora tonkinensis Gagnep. Compound 1 represents an unprecedented polymerization pattern constructed by isoflavone and cytisine. Their structures were elucidated by comprehensive spectroscopic data analysis, combined with ECD calculations. Compound 1 displayed significant anti-tobacco mosaic virus (TMV) activity compared with the positive control ningnanmycin. Moreover, compound 6 exhibited potent α-glucosidase inhibitory activity with IC50 value of 47.4 mg/L.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The work was financially supported by the National Natural Science Foundation of China (U1812403 and 32160103), the Science and Technology Department of Guizhou Province (QKH ZC-[2021]-YB181 and QKH JC-[2020]-1Y398), the Special Project of Academic Young Cultivation and Innovation Exploration of Guizhou Medical University (QKH PTRC [2018] 5779-60).

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