Abstract
A phytochemical investigation on the 90% ethanol extract of the leaves of Croton lachnocarpus Benth. led to three new ent-abietane diterpenoids, 7β,15-dihydroxy-ent-abieta-8,11,13-trien-3-one (1), 2β,15-dihydroxy-ent-abieta-8,11,13-triene (2), and 7β,13α,15-trihydroxy-ent-abieta-8(14)-en-3-one (3). Structural elucidation of all the compounds were performed by spectral methods such as 1 D and 2 D (1H-1H COSY, HMQC, NOESY and HMBC) NMR spectroscopy, in addition to electronic circular dichroism (ECD) spectra. The isolated compounds were tested in vitro for cytotoxic activity against 6 tumor cell lines. As a result, compound 3 exhibited some cytotoxicities against all the tested tumor cell lines with IC50 value less than 30 μM.
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the authors.