Two new withanolides from the whole plants of Physalis peruviana

Abstract

Two new withaphysalin-type withanolides (18-O-ethylwithaphysalin R and 5-O-ethylphysaminimin C, 1 and 2), along with twelve known withanolides (3–14), were purified and identified from Physalis peruviana L. The chemical structures of these new isolates were elucidated through analyzing spectroscopic and HRESIMS data. All the obtained metabolites were appraised for their potential antiproliferative activity against the human breast cancer cell line MCF-7. Compound 7 was discovered to exhibit potent activity with an IC₅₀ value of 3.51 µM and compounds 2, 6 and 14 showed weak cytotoxic effect.

Keywords:

• Solanaceae
• withanolides
• Physalis
• structure elucidation
• antiproliferative activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

Financial support from the National Natural Science Foundation (No. 81903509) is gratefully acknowledged.