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Articles

Four ionones and ionone glycosides from the whole plant of Rehmannia piasezkii

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Pages 955-962 | Received 02 Jun 2022, Accepted 29 Jun 2022, Published online: 19 Jul 2022
 

Abstract

Four new ionones and ionone glycosides (14) were isolated from the whole plant of Rehmannia piasezkii Maxim. Their planar structures as well as absolute configuration were confirmed via spectroscopic analysis, ECD calculation, and X-ray crystallography. Compounds 14 were tested for their cytotoxicity against five human tumor cell lines and ability to inhibit LPS-activated NO production in the BV2 cell line.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by CAMS Initiative for Innovative Medicine [2021-I2M-1-027-4], [2021-I2M-1-028-1] and the State Key Laboratory of Bioactive Substance and Function of Natural Medicines; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College.

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