Abstract
Two new dihydro-β-agarofuran sesquiterpenes chiapen T (1) and chiapen U (2), along with chiapen A (3), 1β-hydroxy-2β,6α,12-triacetoxy-8β-(β-nicotinoyloxy)-9β-(benzoyloxy)-β-dihydroagarofuran (4), wilforlide B (5), 3-hydroxy-2-oxo-3-friedelen-29-oic acid (6), epikatonic acid (7), 22-epi-maytenfolic acid (8), maytenoic acid (9), wilforic acid F (10), wilforic acid B (11), were reported for the first time from the Celastrus angulatus. The structures of all the compounds were elucidated by HR-ESI-MS, 1 D and 2 D NMR spectra, as well as single-crystal X-ray diffraction analyses. Compounds 1 and 2 were examined for anti-inflammatory activity, respectively. None of them showed potent activity.
Graphical Abstract
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Acknowledgments
The authors are grateful to Dr. ZY. Zhang at Shanghai Institute of Materia Medica for the crystallographic data collection. The authors thank the Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences for the measuring the IR, NMR, MS and HR-ESI-MS.
Disclosure statement
No conflict of interest was reported by the authors.