A new cytotoxic disaccharide glycoside from the tubers of Arisaema franchetianum

Abstract

A new disaccharide glycoside, franchoside A (1), and 17 known compounds were isolated from the tubers of Arisaema franchetianum Engler. The chemical structure of the previously undescribed compound 1 was elucidated on the basis of detailed spectroscopic analyses. Compounds 1, 2, 6, 10, 14 and 18 showed significant cytotoxic activities at varying IC₅₀ values in the range of 4.0–10.6 μM against five cancer cell lines. Compounds 8, 10, 13 and 17 (10 μM) exhibited moderate anti-inflammatory activities by inhibiting the NF-κB signaling pathway and the release of NO from RAW264.7 macrophages induced by lipopolysaccharide (LPS), while compounds 1, 9, 14, 15 and 16 showed weak anti-inflammatory activities.

Keywords:

• Araceae
• Arisaema franchetianum
• disaccharide glycoside
• cytotoxicity
• anti-inflammatory activity

Acknowledgements

We are grateful to to Professor Siwang Yu (School of Pharmacy, Peking University) for presenting the SW480 cells, to the Department of Instrumental Analysis, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College for measuring the NMR spectra; to Hongqing Wang for HRESIMS measurements.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was funded by the CAMS Innovation Fund for Medical Science [2021-I2M-1-028].