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Journal of Asian Natural Products Research Volume 26, 2024 - Issue 7
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Research Articles

Two new iridoid glycosides from the whole plant of Rehmania piasezkii

Jie ZhouState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, ChinaView further author information
,
Guo-Ru ShiState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, ChinaView further author information
,
Wan-Qi ZhangState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, ChinaView further author information
,
De-Quan YuState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, ChinaView further author information
&
Yan-Fei LiuState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, ChinaCorrespondence[email protected]
View further author information
Pages 780-787 | Received 12 Jan 2024, Accepted 29 Feb 2024, Published online: 01 Apr 2024
 
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Abstract

Two new iridoid glycosides, piasezkiiosides A (1) and B (2), were isolated from aqueous extract of the whole plant of Rehmannia piasezkii. Their structures were established from the spectroscopic data, chemical transformation, and X-ray diffraction analysis. Compound 1 exhibited weak hepatoprotective activity against APAP-induced HepG2 cell damage.

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Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by CAMS Initiative for Innovative Medicine [2021-I2M-1-027-4], [2021-I2M-1-028-1] and the State Key Laboratory of Bioactive Substance and Function of Natural Medicines; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College.

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