A new canthinone glycoside isolated from the root barks of Ailanthus altissima with NO inhibitory activity

Abstract

One new canthinone glycoside (1), together with six known compounds (2–7) including three lignans (2–4), two coumarins (5–6) and one phenol (7) was isolated from the root barks of Ailanthus altissima. The structure of new compound 1 was established by the interpretation of UV, IR, MS and NMR data, while its absolute configuration was determined by acid hydrolysis and GIAO NMR calculations with DP4+ probability analysis. The inhibitory effects of all compounds on Nitric oxide (NO) production were investigated in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Results showed that compounds 2 and 5 displayed NO production inhibitory activity with IC₅₀ values of 30.1 and 15.3 μM, respectively.

GRAPHICAL ABSTRACT

Keywords:

• Simaroubaceae
• Ailanthus altissima
• canthinone glycoside
• anti-inflammatory activity

Disclosure statement

The authors declare that there is no conflict of interest.

Additional information

Funding

This research work was financially supported by the National Natural Science Foundation of China (82003606), Scientific and Technological Key Project in Henan Province (212102311093), and Scientific Research Nursery Project (MP2020-29).