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Original Articles

Microbial hydroxylation of cinobufagin by Mucor spinosus

, , , , &
Pages 225-229 | Received 06 Nov 2003, Accepted 03 Jan 2003, Published online: 19 Aug 2006
 

Abstract

Mucor spinosus has been employed for the biotransformation of cinobufagin (1) to afford three metabolites. On the basis of their physico-chemical data, the structures of the transformation products have been characterized as 1β-hydroxy-cinobufagin (2), 12β-hydroxy-cinobufagin (3) and 1β,12β-dihydroxy-cinobufagin (4), of which metabolites 2 and 4 are new compounds. In vitro cytotoxic activities of the biotransformation products and the substrate-cinobufagin have been assayed against four tumor cell lines of Bel 7420, BGC 823, HeLa and HL 60; they all showed cytotoxic activities.

Acknowledgements

We thank the National Outstanding Youth Foundation by NSF of China (39925040) and the Trans-Century Training Program Foundation for the Talents by the Ministry of Education for financial support.

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