Novel dimeric alkaloids from the roots of Thalictrum atriplex

Abstract

Two new bisbenzylisoquinoline alkaloids, neothalfine (1) and thaliatrine (2), together with three known dimeric alkaloids, thalifaberine, thalistine, and thalirecebine, have been isolated from the roots of Thalictrum atriplex Finet et Gagnep. Their structures have been established by spectroscopy. Compound 1 showed in vitro antiplatelet aggregation activities.

Keywords:

• Thalictrum atriplex
• Bisbenzylisoquinoline alkaloids
• Neothalfine
• Thaliatrine

Acknowledgements

The authors are grateful to the National Natural Science Foundation of the People's Republic of China for financial support. We thank Professor Wen-Cai Wang for the species identification, and Professor Nan-Nan Gao, Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences, for assistance with the antiplatelet activity assay.