Poriacosones A and B: two new lanostane triterpenoids from Poria cocos

Abstract

Two new lanostane triterpenoids, poriacosones A (8) and B (9), together with eight known compounds were isolated from the sclerotia of Poria cocos (Schw.) Wolf (Polyporaceae), and identified by spectroscopic analysis, including IR, UV, CD, ESI-TOF-MS, HR-SIMS, 1D-, and 2D-NMR spectra. The structures of the new compounds were established as 3α,16α-dihydroxy-24-oxolanost-7,9(11)-dien-21-oic acid (8) and 3β,16α-dihydroxy-24-oxolanost-7,9(11)-dien-21-oic acid (9).

Keywords:

• Poria cocos
• lanostane triterpenoids
• poriacosone A
• poriacosone B

Acknowledgements

This research was supported by the National Natural Science Foundation of China (20572007), the National High Technology Research and Development Program of China (2002AA2Z343C), and the Beijing Municipal Special-purpose Science Foundation of China (Z0004105040311).