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Journal of Asian Natural Products Research Volume 10, 2008 - Issue 11
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Original Articles

An effective O-demethylation of some C19-diterpenoid alkaloids with HBr–glacial acetic acid

Chun-Lan Zou Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, China
,
Hong Ji Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, China
,
Guang-Bo Xie Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, China
,
Dong-Lin Chen Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, China
&
Feng-Peng Wang Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, ChinaCorrespondence[email protected]
Pages 1063-1067 | Received 21 Jan 2008, Accepted 26 May 2008, Published online: 22 Nov 2008
 
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Abstract

The aconitine-type alkaloids talatisamine (1), 8,14-diacetyltalatisamine (11), and compound 3, the lycoctonine-type alkaloid deltaline (5), and the 7,17-seco C19-diterpenoid alkaloids 7 and 9 were treated with HBr–glacial acetic acid to give useful O-demethylated derivatives 2, 2, 4, 6, 8, and 10 respectively in good to high yields (49–90%).

Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 30472075) and the Excellent Ph.D. Dissertation Foundation of China (No. 200367).

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