Metabolites from endophytic fungus S20 of Cephalotaxus hainanensis

Abstract

Three new C-methylated acetogenins, (2E,6Z)-9,10-dihydroxy-4-hydroxymethyl-2,6-decadiene (1), (2E,6Z)-8,9,10-trihydroxy-4-hydroxymethyl-2,6-decadiene (2), and (2E,6Z)-9-hydroxy-4-hydroxymethyl-2,6-nonadiene (3), together with two known compounds, p-hydroxybenzyl alcohol (4) and indolyl-3-carboxylic acid (5), were isolated from endophytic fungus S20 of Cephalotaxus hainanensis Li. Their structures were determined based on HR-ESI-MS and spectroscopic techniques (IR, UV, 1D, and 2D NMR). Compound 5 showed inhibitory effects on Staphylococcus aureus and methicillin-resistant S. aureus by the filter paper disc agar diffusion method.

Keywords:

• Cephalotaxus hainanensis Li
• endophytic fungus
• acetogenins
• antibacterial activity

Acknowledgements

This research was financially supported by National Natural Science Foundation of China (No. 30560018) and National Nonprofit Institute Research Grant of CATAS (No. ITBBZD0841).