Two new sesquiterpene glucosides from the leaves of Nicotiana tabacum

Abstract

Two new sesquiterpene glycosides, 11R,12-dihydroxy-6(7)-spirovetiven-8-one-9-O-β-d-glucopyranoside (1) and rishitin M1-13-O-β-d-glucopyranoside (2), have been isolated from the leaves of Nicotiana tabacum. Their structures were established by spectroscopic methods including ¹H, ¹³C, and 2D NMR. The absolute configuration of the side chain in compound 1 was determined as R by NOESY and NOE difference spectra.

Keywords:

• Nicotiana tabacum
• sesquiterpene glycoside
• absolute configuration
• spirovetiven
• rishitin
• Solanaceae

Acknowledgements

The research work was supported by the Cultivation Fund of the Key Scientific and Technical Innovation Project, Ministry of Education of China (707033).