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Journal of Asian Natural Products Research Volume 12, 2010 - Issue 1
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Original Article

The effect of ultrasound on lipase-catalyzed regioselective acylation of mangiferin in non-aqueous solvents

Original article

Zhi Wang Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, Jilin University, Changchun, 130021, China
,
Ren Wang Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, Jilin University, Changchun, 130021, China
,
Jin Tian Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; College of Chemical Engineering, Shenyang Institute of Chemical Technology, Shenyang, 110142, China
,
Bo Zhao Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, Jilin University, Changchun, 130021, China
,
Xiao-Fei Wei Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, Jilin University, Changchun, 130021, China
,
Ya-Lun Su Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
,
Chun-Yuan Li Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, Jilin University, Changchun, 130021, China
,
Shu-Gui Cao Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, Jilin University, Changchun, 130021, ChinaCorrespondence[email protected]
,
Teng-Fei Ji Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, ChinaCorrespondence[email protected]
&
Lei Wang Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, Jilin University, Changchun, 130021, ChinaCorrespondence[email protected]
 show all
Pages 56-63 | Received 26 Aug 2009, Accepted 21 Oct 2009, Published online: 01 Feb 2010
 
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Abstract

A simple and efficient method for regioselective acylation of mangiferin catalyzed by lipase under ultrasound irradiation is reported. Compared with the conventional methods, its main advantages are shorter reaction time and higher yields. The optimum conditions were screened out. Under the optimal conditions (lipase: PCL, acyl donor: vinyl acetate; reaction solvent: DMSO, reaction temperature: 45°C, ultrasonic power: 200 W; substrate ratio: acyl donor/mangiferin 6/1, enzyme loading: 6 mg/ml), the regioselective acylation yield was up to 84%.

Acknowledgements

The authors are grateful for the financial support from the National Natural Science Foundation of China (No. 20803028) and Science and Technology Development Program of Jilin Province for Youths (20080149).

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