A Versatile Protocol for Synthesis of 2H-Indazolo[2,1-b]Phthalazine Triones Using γ-Al₂O₃/BF_n/Fe₃O₄ as an Efficient Magnetic Nano-Catalyst

Abstract

A four-component reaction of aromatic aldehydes, phthalic anhydride, hydrazine monohydrate and dimedone has been achieved in the presence of nano-γ-Al₂O₃/BF_n/Fe₃O₄ as a highly effective heterogeneous catalyst to produce 2H-indazolo[2,1-b]phthalazine triones. Atom economy, low catalyst loading, reusable catalyst, applicability to a wide range of substrates and high yields of products are some important features of this protocol.

Keywords:

• 2H-Indazolo[2,1-b]phthalazine-triones
• nanocatalyst
• nano-γ-Al2O3/BFn/Fe3O4

Additional information

Funding

The authors are grateful to University of Kashan for supporting this work by Grant No. (159189/403).