One-Pot Synthesis of Quinolinyl Amino Nitriles and Their Antidiabetic, Anti-inflammatory, Antioxidant, and Molecular Docking Studies

Abstract

One-pot synthesis of quinolinyl amine nitriles, 8, was accounted from quinoline-3-carbaldehyde, 7, and amines (benzylic, aromatic, aliphatic, or hetero-aromatic) using Zn(CN)₂/trifluoroethanol (TFE) system, an eco-friendly, and ambient protocol. Antidiabetic, anti-inflammatory, antioxidant, and molecular docking studies of 8a–l revealed moderate-to-good activity.

Keywords:

• Antiamylase
• antidiabetic type 2
• antiglucosidase
• anti-inflammatory
• antioxidant
• ECO friendly reaction
• GLP-1
• molecular docking studies
• quinolinyl amino nitriles;Zn(CN)2;2,2,2-trifluoroethanol

Acknowledgments

Ramesh Dalavai is thankful to Syngene International Ltd, Discovery Chemistry Division, for the lab, NMR and LCMS facilities and permission to carry out this work. We would like to express our special thanks to Dr. Vinay Bharadwaj Tatipamula, from AU College of Pharmaceutical Sciences, Andhra University, for his in vitro anti-inflammatory and antioxidant activities experiments.

Disclosure statement

There are no conflicts of interest.