Design, Synthesis, and Biological Evaluation of Newer Arylidene Incorporated 4-Thiazolidinones Derivatives as Potential Antimicrobial Agents

Abstract

A series of newer derivatives 10a–n containing a 2,4-thiazolidinedione and 2-aryl-4-thiazolidinone moieties of pharmacological significance have been synthesized. The compounds were screened for their in vitro antimicrobial activity against three Gram-positive bacteria Staphylococcus aureus, Bacillus cereus, and Micrococcus luteus and three Gram-negative bacteria Pseudomonas fluorescens, Escherichia coli, and Flavobacterium devorans. Among them,10c, 10d, 10i, 10j, 10k, 10l, and 10n displayed equipotent antibacterial activity against the tested strains. All synthesized compounds were also tested for their cytotoxic activity against HeLa and MCF-7 cell lines. This study shows that all compounds were non-cytotoxicin nature, and confirmed their antimicrobial specificity apart from any general cytotoxicity. All these synthesized compounds were characterized by ¹H NMR, ¹³C NMR, and HRMS spectral techniques.

Keywords:

• Arylidene
• 4-thiazolidinones
• 24-thiazolidinedione
• antimicrobial activity
• knoevenagel condensation
• cyclocondensation

Acknowledgments

We are thankful to Dr. J. D, Kabra, Principal J.E.S. College Jalna, for providing laboratory facilities and kind support in the completion of this work.

Disclosure statement

The authors declare no conflict of interest, financial or otherwise.