Synthesis of New Biological Functionalized Tetra Pyrimidodipyrimidines and Tetra Barbituric Moiety Conation Ether Groups

Abstract

One-pot three-component reactions of tetra aromatic aldehyde, including ether groups, derivatives of barbituric acid with ammonia, and ammonium acetate, result in new poly barbituric moiety and, correspondingly, tetra pyrimidodipyrimidine heterocycles. IR, ¹H-NMR, and ¹³C-NMR spectroscopy along with CHN analyses were used to derive the structures of the products. Moreover, the synthesized compounds were investigated in terms of biological performance, consisting of toxicity examination, along with antioxidant, anti-inflammatory, and antibacterial activities.

Keywords:

• Tetra aldehyde
• barbituric acid
• tetra pyrimidodipyrimidine
• biological activity
• ether group

Acknowledgments

The authors are grateful to Islamic Azad University (Kerman Branch).

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

Islamic Azad University is highly appreciated for its financial support to our research group.