Abstract
Citric acid was discovered as an efficient catalyst for the rapid synthesis of pharmacologically important isoniazid azomethines by condensation of aromatic aldehydes and isatins with isoniazid in aqueous ethanol under reflux condition. The advantages of the described method include the use of readily available starting materials, biodegradable greener catalyst, and mild reaction conditions. The products were obtained in high yield within short reaction time and no need for column chromatography purification.
Graphical Abstract
Acknowledgments
The author YBW are grateful to Council of Scientific & Industrial Research (CSIR), New Delhi, India for the postdoctoral research fellowship under CSIR-RA [Award No. 09/728(0036)/2019 (EMR-I)]. The authors are grateful to UGC, New Delhi for financial assistance under Major Research Project [F. No. 43-173/2014 (SR)].
Disclosure statement
The authors declare no competing financial interest