Synthesis, Characterization and Insecticidal Activity against Cotton Leaf Worm of New Heterocyclics Which Scaffold on Hydrazide-Hydrazone Derivative

Abstract

A new hydrazide-hydrazone has been designed and synthesized by combining p-aminoacetophenone with cyanoacetohydrazide followed by acetylation. Afterwards, it was utilized as scaffold to synthesize different arylidenes, heteroarylidenes and heterocycles. The structures of these compounds were proved clearly based on their spectral and analytical data. The insecticidal activity for the newly synthesized compounds was tested against cotton leaf worm (Spodoptera littoralis). The obtained data indicated that, 2,4-dichlorobenzylidenecyanoacetohydrazide derivative 14c is the most potent one after methoxyfenozide (LC₅₀ = 51.75 μg/ml) where its LC₅₀ was (79.73 μg/ml). Interestingly, we recommended to use arylidene derivative 14c in the field of pest control after its formulation.

Graphical Abstract

Keywords:

• Hydrazide-hydrazone derivatives
• cyanoacetohydrazide
• 2-iminochromene derivatives
• arylidene derivatives
• insecticidal activity
• cotton leaf worm

Disclosure statement

No potential conflict of interest was reported by the authors.