Abstract
In this article, a new and simple procedure was designed for the preparation of pyrazolopyranopyrimidine and dihydropyrano[2,3-c]pyrazole derivatives using the reaction between hydrazine hydrate, aryl aldehydes, malononitrile or barbituric acid, and ethyl acetoacetate using Fe3O4@THAM-piperazine as a solid nanocatalyst in a solution of water and ethanol at 60 °C. The present process offers advantages like easy workup, short reaction time, non-toxicity, and the use of green solvent. Moreover, recyclability studies were carried out that showed a high potential of reusing and recovering capability.
Graphical Abstract
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Acknowledgments
The authors gratefully appreciate the financial support from the Research Council of University of Sistan and Baluchestan.
Disclosure statement
No potential conflict of interest was reported by the author(s).