Baker’s Yeast Promoted Facile Synthesis of Spirooxadiazepines Using Multicomponent Reactions of Ninhydrin: Investigation of Biological Activity

Abstract

In this research, new derivatives of spirooxadiazepines were prepared using multicomponent reactions (MCRs) of ninhydrin, secondary amines, Melderum’s acid, carbonyl compounds such as aldehyde or ketones and hydrazonoyl chloride in water at room temperature in the presence of baker’s yeast as catalyst in good yields. The short time of reaction, high yields of product, and easy separation of them are some advantages of this procedure. Another work in this research is investigation of antioxidant property of some synthesized compounds by diphenyl-picrylhydrazine (DPPH) radical trapping experiment. Presently, bacteria that are not destroyed with drug have generated many problems in the performance of many transferable disease. For this reason, discovering appropriate and new procedures for the dealing with these pathogens are important and recent study have focused on the investigation of the antibacterial effects on the prepared compounds.

Graphical Abstract

Highlights

• Green chemistry is the use of a set of principles to reduce or eliminate the use or generation of unsafe materials in the design, fabrication, and applications of chemical products. Among solvents, water is a green solvents and very suitable for performing organic reaction.

• The present procedure avoids the use of toxic solvent.

Keywords:

• Baker’s yeast
• spiropyrrolidines
• five component reactions
• Melderum acid
• ninhydrin

Disclosure statement

No potential conflict of interest was reported by the author(s).