MNPs@PBI-CuBr₂ Nanocomposite Catalyzed One-Pot Three-Component Reaction of 2-Aminobenzoazoles, Sulfonyl Chloride and Aryl Iodides

Abstract

Sulfonamides are widely used in the treatment of many diseases due to their biological and pharmacological activities. In this paper, we prepared Cu(II) complex immobilized on the surface of magnetic Fe₃O₄ nanoparticles functionalized with 2-Pyridine Benzoimidazole ligand [MNPs@PBI-CuBr₂] and its catalytic activity in the synthesis of N-aryl sulfonamides containing benzoxazole scaffolds through one-pot three-component reaction of 2-aminobenzoazoles, sulfonyl chloride and aryl iodides under ecofriendly conditions. The structure of the as-prepared MNPs@PBI-CuBr₂ nanomaterial was well characterized by a number of spectroscopic techniques such as FTIR, SEM, EDX, TEM, XRD, TGA, VSM, MAP, XPS and ICP-OES. The MNPs@PBI-CuBr₂ nanocatalyst was simply separated by magnetic separation and reused for seven times with constant activity. The TEM, XRD pattern and ICP-OES spectroscopy of catalyst after recycling were studied and the results were similar to before of utilization.

Keywords:

• MNPs@PBI-CuBr₂ nanocatalyst
• N-aryl sulfonamides
• ecofriendly conditions
• magnetic separation

Acknowledgment

The authors extend their appreciation to the Deanship of Scientific Research at King Khalid University, KSA, for funding this work through a large research group program under grant number RGP 2/233/43.

Disclosure statement

No potential conflict of interest was reported by the author(s).