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Abstract
In this research new derivatives of pyrroles in good yields were prepared using multicomponent reactions of amoxicillin, activated acetylenic compounds, and alkyl bromides in water as solvent at room temperature in the presence of catalytic amounts of active carbon. The short time of reaction, high yields of product, and easy separation of them are some advantages of this procedure. In this research, the adsorption process was investigated for cefixime and amoxicillin as antibiotic drugs removal using active carbon and zeolite as organic and natural adsorbents in continuous and batch reactors in lab-scale, and the experiments were continued continuously using an adsorbent that absorbed more the two drugs. According to obtained results, the active carbon adsorbed both cefixime and amoxicillin but the zeolite did not adsorb the amoxicillin but adsorbed the high percentage of cefixime in the batch procedure. It can be concluded that some advantages of the continuous process compared to batch reactor are high performance of adsorbent, short time of process, and high percentage of adsorption.
GRAPHICAL ABSTRACT
HIGHLIGHTS
Green chemistry is the use of a set of principles to reduce or eliminate the use or generation of unsafe materials in the design, fabrication, and applications of chemical products. Among solvents, water is a green solvent and very suitable for performing organic reaction.
The present procedure avoids the use of toxic solvents.
According to obtained results, the active carbon adsorbed both cefixime and amoxicillin, but the zeolite did not adsorb the amoxicillin but adsorbed the high percentage of cefixime in the batch procedure.