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Prognostic factors in 264 adults with invasive Scedosporium spp. and Lomentospora prolificans infection reported in the literature and FungiScope^®

Danila SeidelDepartment I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; ;Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany;

http://orcid.org/0000-0003-4388-3117

Arne MeißnerDepartment I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; ;Department of Hospital Hygiene and Infection Control, University Hospital Cologne, Cologne, Germany;

Michaela LacknerDivision of Hygiene and Medical Microbiology, Medical University of Innsbruck (MUI), Innsbruck, Austria;

http://orcid.org/0000-0001-9073-2886

Ellen PiepenbrockDepartment of Immunology and Hygiene, Institute for Medical Microbiology, University of Cologne, Cologne, Germany;

Jon Salmanton-GarcíaDepartment I of Internal Medicine, University Hospital of Cologne, Cologne, Germany;

http://orcid.org/0000-0002-6766-8297

Melanie StecherDepartment I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; ;Partner site Bonn - Cologne, German Centre for Infection Research (DZIF), Cologne, Germany;

Sibylle MellinghoffDepartment I of Internal Medicine, University Hospital of Cologne, Cologne, Germany;

http://orcid.org/0000-0003-3928-2503

Axel HamprechtDivision of Hygiene and Medical Microbiology, Medical University of Innsbruck (MUI), Innsbruck, Austria;

http://orcid.org/0000-0003-1449-5780

Luisa Durán GraeffDepartment I of Internal Medicine, University Hospital of Cologne, Cologne, Germany;

http://orcid.org/0000-0001-5110-6356

Philipp KöhlerDepartment I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; ;Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany; ;Partner site Bonn - Cologne, German Centre for Infection Research (DZIF), Cologne, Germany;

http://orcid.org/0000-0002-7386-7495

Matthew P. ChengDivision of Infectious Diseases and Department of Medical Microbiology, McGill University Health Centre, Montreal, Canada;

http://orcid.org/0000-0002-4867-2063

Julie DenisHôpitaux Universitaires, Department of Parasitology and Mycology, Plateau Technique de Microbiologie, FMTS, Université de Strasbourg, Strasbourg, France;

Isabelle ChedotalOncology and Hematology Department, University Hospital of Strasbourg and INSERM U1113, Strasbourg, France;

Jagdish ChanderDepartment of Microbiology, Government Medical College Hospital, Chandigarh, India;

Diana Lynn PakstisInfectious Diseases, Falk Medical Building, Pittsburgh, PA, USA;

Ibai Los-ArcosInfectious Diseases Department, Hospital Universitari Vall d’Hebron, Barcelona, Spain;

http://orcid.org/0000-0001-8835-2702

Monica SlavinUniversity of Melbourne, Melbourne, Australia, The National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Melbourne, Australia;

http://orcid.org/0000-0002-8443-314X

Maria Teresa MontagnaDepartment of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy;

http://orcid.org/0000-0002-2958-5458

Giuseppina CaggianoDepartment of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy;

http://orcid.org/0000-0003-3009-9147

Mihai MaresLaboratory of Antimicrobial Chemotherapy, Ion Ionescu de la Brad University, Iași, Romania;

http://orcid.org/0000-0002-3103-4954

Janina TrauthMedical Clinic II – Infectious Diseases, University Hospital Giessen/Marburg, Giessen, Germany;

Ute AurbachLaboratory Dr. Wisplinghoff, Cologne, Germany;

Maria J. G. T. VehreschildDepartment I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; ;Partner site Bonn - Cologne, German Centre for Infection Research (DZIF), Cologne, Germany; ;Center for Integrated Oncology CIO Köln/Bonn, Medical Faculty, University of Cologne, Cologne, Germany;

http://orcid.org/0000-0002-7282-2842

Jörg Janne VehreschildDepartment I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; ;Partner site Bonn - Cologne, German Centre for Infection Research (DZIF), Cologne, Germany; ;Center for Integrated Oncology CIO Köln/Bonn, Medical Faculty, University of Cologne, Cologne, Germany;

http://orcid.org/0000-0002-5446-7170

Rafael F. DuarteHospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain;

Raoul HerbrechtOncology and Hematology Department, University Hospital of Strasbourg and INSERM U1113, Strasbourg, France;

http://orcid.org/0000-0002-9381-4876

Hilmar WisplinghoffDepartment of Immunology and Hygiene, Institute for Medical Microbiology, University of Cologne, Cologne, Germany; ;Laboratory Dr. Wisplinghoff, Cologne, Germany; ;Institute for Virology and Clinical Microbiology, Witten/Herdecke University, Witten, Germany;

Oliver A. CornelyDepartment I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; ;Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany; ;Partner site Bonn - Cologne, German Centre for Infection Research (DZIF), Cologne, Germany; ;Center for Integrated Oncology CIO Köln/Bonn, Medical Faculty, University of Cologne, Cologne, Germany; ;Clinical Trials Centre Cologne (ZKS Köln), University of Cologne, Cologne, Germany; ;Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; Correspondence[email protected]

http://orcid.org/0000-0001-9599-3137

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Figures & data

Figure 1. Geographical distribution of (A) 208 scedosporiosis cases and (B) 56 lomentosporiosis cases identified in the literature and FungiScope^® presented as number of cases per million population. United States (n = 57), Australia, Germany (n = 17 each), India (n = 16), Japan (n = 14), France (n = 11), Spain (n = 10), China, Italy, The Netherlands (n = 7 each), South Korea, Turkey (n = 5 each), Austria (n = 4), Belgium, Canada, Thailand (n = 3 each), Chile, New Zealand, Portugal, Taiwan, Switzerland, United Kingdom (n = 2 each), Brazil, Finland, Greece, Hungary, Ireland, Israel, Lebanon, Malaysia, Romania, Slovenia (n = 1 each). Australia (n = 14), Japan, United States (n = 8 each), Spain (n = 7), France, Germany (n = 5 each), India, Italy, United Kingdom (n = 2 each), Brazil, The Netherlands, Poland (n = 1 each).

Table 1. Site of infection by dominant risk factor in 208 Scedosporium spp. and 56 L. prolificans infections.

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Table 2. Treatment administered to 208 patients with Scedosporium spp. and 56 L. prolificans infection.

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Table 3. All-cause mortality overall and at day 42 in patients with Scedosporium spp. (n = 205) and L. prolificans (n = 55) infection.

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Table 4. Median minimum inhibitory concentrations in Scedosporium spp. and L. prolificans clinical isolates assessed using the EUCAST and CLSI procedures.

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Supplemental material

Supplementary Figure 1.pdf

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Prognostic factors in 264 adults with invasive Scedosporium spp. and Lomentospora prolificans infection reported in the literature and FungiScope^®

Table 1. Site of infection by dominant risk factor in 208 Scedosporium spp. and 56 L. prolificans infections.

Table 2. Treatment administered to 208 patients with Scedosporium spp. and 56 L. prolificans infection.

Table 3. All-cause mortality overall and at day 42 in patients with Scedosporium spp. (n = 205) and L. prolificans (n = 55) infection.

Table 4. Median minimum inhibitory concentrations in Scedosporium spp. and L. prolificans clinical isolates assessed using the EUCAST and CLSI procedures.

Supplementary Figure 1.pdf

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Prognostic factors in 264 adults with invasive Scedosporium spp. and Lomentospora prolificans infection reported in the literature and FungiScope®

Figures & data

Table 1. Site of infection by dominant risk factor in 208 Scedosporium spp. and 56 L. prolificans infections.

Table 2. Treatment administered to 208 patients with Scedosporium spp. and 56 L. prolificans infection.

Table 3. All-cause mortality overall and at day 42 in patients with Scedosporium spp. (n = 205) and L. prolificans (n = 55) infection.

Table 4. Median minimum inhibitory concentrations in Scedosporium spp. and L. prolificans clinical isolates assessed using the EUCAST and CLSI procedures.

Supplementary Figure 1.pdf

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Prognostic factors in 264 adults with invasive Scedosporium spp. and Lomentospora prolificans infection reported in the literature and FungiScope^®